2021

Mawla AM, van der Meulen T, Huising MO. 2021. Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers.
bioRxiv.


Mawla AM, Huising MO. 2021. epiRomics: a multi-omics R package to identify and visualize enhancers.
bioRxiv.


Github Repository Link
Package Documentation

Lee S, Zhang J, Saravanakumar S, Flisher MF, Grimm DR, van der Meulen T, Huising MO. 2021. Virgin beta cells at the neogenic niche proliferate normally and mature slowly.
Diabetes.


Croze ML, Flisher MF, Guillaume A, Tremblay C, Noguchi GM, Granziera S, Vivot K, Castillo VC, Campbell SA, Ghislain J, Huising MO, Poitout V. 2021. Free fatty-acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.
Molecular Metabolism, 101166:2212-8778.

2020

Huising MO. 2020. Paracrine regulation of insulin secretion.
Diabetologia, 63(10): 2057-2063.


Huang JL, Lee S, Hoek P, van der Meulen T, Van R, Huising MO. 2020. Genetic deletion of Urocortin 3 does not prevent functional maturation of beta cells.
Journal of Endocrinology, 246(1): 69-78.


2019

Noguchi GM, Huising MO. 2019. Integrating the inputs that shape pancreatic islet hormone release.
Nature Metabolism, (1): 1189–1201.


Mawla AM, Huising MO. 2019. Navigating the Depths and Avoiding the Shallows of Pancreatic Islet Cell Transcriptomes.
Diabetes, 68(7): 1380-1393.


2018

Huising MO, Lee S, van der Meulen T. 2018. Evidence for a Neogenic Niche at the Periphery of Pancreatic Islets.
BioEssays, 40(11):e1800119.


Featured Editorial in BioEssays.

Huising MO, van Der Meulen T, Huang JL, Pourhosseinzadeh MS, Noguchi GM. 2018. The Difference δ-Cells Make in Glucose Control.
Physiology, 33(6):403-411

Featured Editorial in Physiology.

Rorsman P, Huising MO. 2018. The somatostatin-secreting pancreatic δ-cell in health and disease.
Nature Reviews Endocrinology, 27(1):218-225.

van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM, Mawla AM, Huising MO. 2018. Artemether Does Not Turn α Cells into β Cells.
Cell Metabolism, 27(1):218-225.




2017

van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO. 2017. Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.
Cell Metabolism, 25(4):911-926.

2017/2018 UC Davis College of Biological Science Faculty Research Award

Datasets

2016

DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, van der Meulen T, Huising MO. 2016. Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets.
Molecular Metabolism, 5(7):449–458.

Featured Editorial in Molecular Metabolism.

Datasets

2015

van der Meulen T, Donaldson CJ, Caceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO. 2015 Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.
Nature Medicine, 21(7):769-776.

Featured Editorial in Science Signaling.

Datasets

Huising MO. 2015 Tuning to the right signal. Diabetologia, 58(6):1146-1148.

van der Meulen T and Huising MO. 2015 Role of transcription factors in the transdifferentiation of pancreatic islet cells.
Journal of Molecular Endocrinology, 54(2):R103-117.




2014

Benner C, van der Meulen T, Caceres E, Tigyi K, Donaldson CJ, Huising MO. 2014 The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.
BMC Genomics 15(1):620.

Datasets

van der Meulen T, Huising MO. 2014 Maturation of Stem Cell-Derived Beta cells Guided by the Expression of Urocortin 3.
The Review of Diabetic Studies, 11(1):115-132.





2012

van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO. 2012 Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells.
PLoS ONE, 7(12):e52181.



2011

Huising MO, Pilbrow A, Matsumoto M, van der Meulen T, Park H, Donaldson CJ, Vaughan JM, Lee, SL, Vale WW. 2011 Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2a in MIN6 insulinoma cells and rodent islets.
Endocrinology, 152(1):138-150.


2010

Huising MO, van der Meulen T, Vaughan JM, Donaldson CJ, Park H, Billestrup N, Vale WW. 2010 Corticotropin releasing factor receptor 1 (CRFR1) is expressed on pancreatic b cells, promotes b cell proliferation and potentiates insulin secretion in an incretin-like manner.
Proceedings of the National Academy of Sciences USA, 107(2):912-917.

Featured in the Wall Street Journal.

2008

Huising MO, Vaughan JM, Shah SH, Grillot KL, Donaldson CJ, Rivier J, Flik G, Vale WW. 2008 Residues of corticotropin releasing factor-binding protein (CRF-BP) that selectively abrogate binding to CRF but not to urocortin 1.
Journal of Biological Chemistry, 283(14):8902-8912.