2017

van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO. 2017. Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.
Cell Metabolism, 25(4):911-926.

Datasets


2016

DiGruccio MR, Mawla AM, Donaldson CJ, Noguchi GM, Vaughan J, Cowing-Zitron C, van der Meulen T, Huising MO. 2016. Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets.
Molecular Metabolism, 5(7):449–458.

Featured Editorial in Molecular Metabolism.

Datasets


2015

van der Meulen T, Donaldson CJ, Caceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO. 2015 Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.
Nature Medicine, 21(7):769-776.

Featured Editorial in Science Signaling.

Datasets


Huising MO. 2015 Tuning to the right signal. Diabetologia, 58(6):1146-1148.


van der Meulen T and Huising MO. 2015 Role of transcription factors in the transdifferentiation of pancreatic islet cells.
Journal of Molecular Endocrinology, 54(2):R103-117.



2014

Benner C, van der Meulen T, Caceres E, Tigyi K, Donaldson CJ, Huising MO. 2014 The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.
BMC Genomics 15(1):620.

Datasets


van der Meulen T, Huising MO. 2014 Maturation of Stem Cell-Derived Beta cells Guided by the Expression of Urocortin 3.
The Review of Diabetic Studies, 11(1):115-132.



2012

van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO. 2012 Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells.
PLoS ONE, 7(12):e52181.



2011

Huising MO, Pilbrow A, Matsumoto M, van der Meulen T, Park H, Donaldson CJ, Vaughan JM, Lee, SL, Vale WW. 2011 Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2a in MIN6 insulinoma cells and rodent islets.
Endocrinology, 152(1):138-150.



2010

Huising MO, van der Meulen T, Vaughan JM, Donaldson CJ, Park H, Billestrup N, Vale WW. 2010 Corticotropin releasing factor receptor 1 (CRFR1) is expressed on pancreatic b cells, promotes b cell proliferation and potentiates insulin secretion in an incretin-like manner.
Proceedings of the National Academy of Sciences USA, 107(2):912-917.

Featured in the Wall Street Journal.


2008

Huising MO, Vaughan JM, Shah SH, Grillot KL, Donaldson CJ, Rivier J, Flik G, Vale WW. 2008 Residues of corticotropin releasing factor-binding protein (CRF-BP) that selectively abrogate binding to CRF but not to urocortin 1.
Journal of Biological Chemistry, 283(14):8902-8912.